Sandbox1313

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==Lysyl-tRNA Synthase==

Shown here is PDB number 1bbu, lysyl-tRNA Synthase shown here complexed with the lysine substrate. It consists of both alpha helices and beta sheets (the latter in sheets and a barrel). Below is pictured the exact same synthase complexed with it's residue of interest, lysine.



In the active site, the bound lysine participates in multiple hydrogen bonding interactions to stay complexed to the synthase protein as it moves into position to build the tRNA in the ribosome. Specifically, these residues trigger a complex conformational change that completely changes the shape of part of the synthase. These changes involve these two loops and some other pieces of the molecule. This conformational change effectively closes the active site when bound to lysine.